Novel Mechanisms of Protection Against Acetaminophen Hepatotoxicity in Mice by Glutathione and N-Acetylcysteine

2009430 citationsJournal Article

Authors

Chieko Saito · University of Kansas Medical Center

Hartmut Jaeschke · University of Kansas Medical Center

Abstract

Delayed treatment with GSH and NAC protect against APAP overdose by dual mechanisms-that is, by enhancing hepatic and mitochondrial GSH levels (scavenging of reactive oxygen and peroxynitrite)-and by supporting the mitochondrial energy metabolism.

Topics & Keywords

Drug-Induced Hepatotoxicity and Protection Liver Disease and Transplantation Drug Transport and Resistance Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 51, Issue 1, pp. 246-254

DOI: 10.1002/hep.23267

Field-Weighted Citation Impact: 17.57