Multivalent Peptide and Protein Dendrimers Using Native Chemical Ligation

A wide variety of well-defined multivalent peptides and proteins can be made by conjugating synthetic peptides and recombinantly expressed proteins to cysteine-functionalized dendrimers using native chemical ligation (see picture). This modular approach provides access to dendrimers that are attractive both for understanding fundamental issues of multivalency in biological interactions as well as for biomedical applications. Supporting information (synthesis and characterization of the dendrimers, including mass spectra for all the peptide and protein dendrimers) for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500635_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.