Artemisinin Resistance in <i>Plasmodium falciparum</i> Malaria

20093,431 citationsJournal Articlebronze Open Access

Authors

Arjen M. Dondorp · Mahidol Oxford Tropical Medicine Research Unit

François Nosten · Mahidol University

Poravuth Yi · Cambodia National Malaria Center

Debashish Das · Mahidol Oxford Tropical Medicine Research Unit

Aung Pyae Phyo · Shoklo Malaria Research Unit

Joel Tärning · Mahidol Oxford Tropical Medicine Research Unit

Khin Maung Lwin

Abstract

P. falciparum has reduced in vivo susceptibility to artesunate in western Cambodia as compared with northwestern Thailand. Resistance is characterized by slow parasite clearance in vivo without corresponding reductions on conventional in vitro susceptibility testing. Containment measures are urgently needed. (ClinicalTrials.gov number, NCT00493363, and Current Controlled Trials number, ISRCTN64835265.)

Topics & Keywords

Malaria Research and Control Mosquito-borne diseases and control Drug-Induced Hepatotoxicity and Protection

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 5, pp. 455-467

DOI: 10.1056/nejmoa0808859

Field-Weighted Citation Impact: 220.88