Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

20061,037 citationsJournal Articlegold Open Access

Authors

Anju Singh · Johns Hopkins University

Vikas Misra · Johns Hopkins University

Rajesh K. Thimmulappa · Johns Hopkins University

Hannah Lee · Johns Hopkins University

Stephen Ames · Sidney Kimmel Comprehensive Cancer Center

Mohammad Obaidul Hoque · Johns Hopkins University

James G. Herman

Abstract

This is the first study to our knowledge to demonstrate that biallelic inactivation of KEAP1 is a frequent genetic alteration in NSCLC. Loss of KEAP1 function leading to constitutive activation of NRF2-mediated gene expression in cancer suggests that tumor cells manipulate the NRF2 pathway for their survival against chemotherapeutic agents.

Topics & Keywords

Genomics, phytochemicals, and oxidative stress Nitrogen and Sulfur Effects on Brassica Glutathione Transferases and Polymorphisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 3, Issue 10, pp. e420-e420

DOI: 10.1371/journal.pmed.0030420

Field-Weighted Citation Impact: 10.72