Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy.

2003657 citationsJournal Article

Authors

Matthew Bui

David B. Seligson · University of California, Los Angeles

K R Han · University of California, Los Angeles

Allan J. Pantuck · University of California, Los Angeles

Frederick J. Dorey · University of California, Los Angeles

Yunda Huang · University of California, Los Angeles

Steve Horvath · University of California, Los Angeles

Abstract

On the basis of our data, CAIX is the most significant molecular marker described in kidney cancer to date. Decreased CAIX levels are independently associated with poor survival in advanced RCC. CAIX reflects significant changes in tumor biology, which should be used to predict clinical outcome and identify high-risk patients in need for adjuvant immunotherapy and CAIX-targeted therapies.

Topics & Keywords

Renal cell carcinoma treatment Enzyme function and inhibition Renal and related cancers

UN Sustainable Development Goals

No poverty

Publication Details

Published in: PubMed

Volume 9, Issue 2, pp. 802-11

Field-Weighted Citation Impact: 26.66