Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

20122,010 citationsJournal Articlebronze Open Access

Authors

Michael C. Thigpen · Centers for Disease Control and Prevention

Poloko Kebaabetswe

Sonal Pathak · Northrop Grumman (United States)

Fatma Soud

Kata Chillag

Rodreck Mutanhaurwa

Abstract

Daily TDF-FTC prophylaxis prevented HIV infection in sexually active heterosexual adults. The long-term safety of daily TDF-FTC prophylaxis, including the effect on bone mineral density, remains unknown. (Funded by the Centers for Disease Control and Prevention and the National Institutes of Health; TDF2 ClinicalTrials.gov number, NCT00448669.).

Topics & Keywords

HIV/AIDS Research and Interventions HIV, Drug Use, Sexual Risk Sex work and related issues

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 367, Issue 5, pp. 423-434

DOI: 10.1056/nejmoa1110711

Field-Weighted Citation Impact: 99.33