Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

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Authors

Massimo Federici · Columbia University

Rossella Menghini · Columbia University

Alessandro Mauriello · Columbia University

Marta Letizia Hribal · Columbia University

Francesca Ferrelli · Columbia University

Davide Lauro · Columbia University

Paolo Sbraccia ·

Abstract

Our data show that hyperglycemia, through the hexosamine pathway, impairs activation of the IR/IRS/PI3-K/Akt pathway, resulting in deregulation of eNOS activity.

Topics & Keywords

Glycosylation and Glycoproteins Research Galectins and Cancer Biology Atherosclerosis and Cardiovascular Diseases

Publication Details

Published in: Circulation

Volume 106, Issue 4, pp. 466-472

DOI: 10.1161/01.cir.0000023043.02648.51

Field-Weighted Citation Impact: 6.28

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Insulin-Dependent Activation of Endothelial Nitric Oxide Synthase Is Impaired by O-Linked Glycosylation Modification of Signaling Proteins in Human Coronary Endothelial Cells

Authors

Abstract

Topics & Keywords

Publication Details