Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity

2011166 citationsJournal Articlebronze Open Access

Authors

Naila Rabbani

Lisa Godfrey

Mingzhan Xue

Fozia Shaheen

Michèle Geoffrion · Ottawa Heart Institute

Ross W. Milne · Ottawa Heart Institute

Paul J. Thornalley

Abstract

MG modification of LDL forms small, dense LDL with increased atherogenicity that provides a new route to atherogenic LDL and may explain the escalation of cardiovascular risk in diabetes and the cardioprotective effect of metformin.

Topics & Keywords

Advanced Glycation End Products research Diabetes, Cardiovascular Risks, and Lipoproteins Alcohol Consumption and Health Effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 60, Issue 7, pp. 1973-1980

DOI: 10.2337/db11-0085

Field-Weighted Citation Impact: 9.45