Synthesis and Antimicrobial Screening of Some Novel 2, 5‐Disubstituted 1, 3, 4‐oxadiazole Derivatives

The syntheses of series of 2, 5‐disubstituted 1, 3, 4‐oxadiazole derivatives are described. A total of twelve new compounds were synthesized and characterized by IR, 1 H‐NMR and Mass spectral data. All newly synthesized compounds were screened for their antimicrobial activity i.e . antibacterial activity against S. aureus and E. coli and antifungal activity against fungus A. nigar . Compounds G5 and G7 exhibited significant both antibacterial and antifungal activity while G2 , G10 and G3 , G9 showed antibacterial and antifungal activity respectively. These compounds were 2, 5‐disubstituted 1, 3, 4‐oxadiazole moiety at position two and five showed reasonable antibacterial and antifungal activity.