Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle

2010312 citationsJournal Articlebronze Open Access

Authors

Alexey V. Glukhov · Washington University in St. Louis

Vadim V. Fedorov · Mohammed V University

Qing Lou · Washington University in St. Louis

Vinod K. Ravikumar · Mohammed V University

Paul W. Kalish · Washington University in St. Louis

Richard B. Schuessler · Washington University in St. Louis

Nader Moazami

Abstract

We present for the first time direct experimental evidence of a transmural APD gradient in the human heart. HF results in the heterogeneous prolongation of APD, which significantly reduces the transmural and local APD gradients.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Cardiac Arrhythmias and Treatments Ion channel regulation and function

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Circulation Research

Volume 106, Issue 5, pp. 981-991

DOI: 10.1161/circresaha.109.204891

Field-Weighted Citation Impact: 21.69