Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

20151,976 citationsJournal Articlebronze Open Access

Authors

Xiaofang Sun · Third Affiliated Hospital of Guangzhou Medical University

Zhanhui Ou · Guangzhou Medical University

Ruochan Chen · UPMC Hillman Cancer Center

Xiaohua Niu · Guangzhou Medical University

De Chen · Third Affiliated Hospital of Guangzhou Medical University

Rui Kang · UPMC Hillman Cancer Center

Daolin Tang

Abstract

These findings demonstrate novel molecular mechanisms and signaling pathways of ferroptosis; the status of NRF2 is a key factor that determines the therapeutic response to ferroptosis-targeted therapies in HCC cells.

Topics & Keywords

Ferroptosis and cancer prognosis RNA modifications and cancer Genomics, phytochemicals, and oxidative stress

Publication Details

Published in: Hepatology

Volume 63, Issue 1, pp. 173-184

DOI: 10.1002/hep.28251

Field-Weighted Citation Impact: 24.92

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Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Authors

Abstract

Topics & Keywords

Publication Details