PET of Brain Amyloid and Tau in Mild Cognitive Impairment

2006732 citationsJournal Article

Authors

Gary W. Small · Neurobehavioral Systems

Vladimir Kepe

Linda M. Ercoli

Prabha Siddarth

Susan Y. Bookheimer · Brain Mapping Foundation

Karen J. Miller

Helen Lavretsky

Alison C. Burggren · Brain Mapping Foundation

Greg M. Cole · Alzheimer’s Disease Neuroimaging Initiative

Abstract

FDDNP-PET scanning can differentiate persons with mild cognitive impairment from those with Alzheimer's disease and those with no cognitive impairment. This technique is potentially useful as a noninvasive method to determine regional cerebral patterns of amyloid plaques and tau neurofibrillary tangles.

Topics & Keywords

Alzheimer's disease research and treatments Functional Brain Connectivity Studies Medical Imaging Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 355, Issue 25, pp. 2652-2663

DOI: 10.1056/nejmoa054625

Field-Weighted Citation Impact: 46.78