Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

2011132 citationsJournal Articlegold Open Access

Authors

Wei Zhao · Icahn School of Medicine at Mount Sinai

Merina Varghese · Geriatric Research Education and Clinical Center

Shrishailam Yemul · Geriatric Research Education and Clinical Center

Yong Pan · Geriatric Research Education and Clinical Center

Alice Cheng · Icahn School of Medicine at Mount Sinai

Paul Marano · Icahn School of Medicine at Mount Sinai

Sadiq Hassan

Abstract

Our results demonstrate that PGC-1α plays a beneficial role in a mouse model of ALS, suggesting that PGC-1α may be a potential therapeutic target for ALS therapy.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Neurogenetic and Muscular Disorders Research Parkinson's Disease Mechanisms and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Neurodegeneration

Volume 6, Issue 1, pp. 51-51

DOI: 10.1186/1750-1326-6-51

Field-Weighted Citation Impact: 7.30