A New Tri-Fab Bispecific Antibody for Pretargeting Trop-2–Expressing Epithelial Cancers

201243 citationsJournal Articlebronze Open Access

Authors

Robert M. Sharkey · Center for Molecular Medicine and Immunology

Catharina M. van Rij · Radboud University Nijmegen

Habibe Karacay · Center for Molecular Medicine and Immunology

Edmund A. Rossi · Immunomedics (United States)

Cathelijne Frielink · Radboud University Medical Center

Celeste A.S. Regino · Immunomedics (United States)

Thomas M. Cardillo

Abstract

TF12 was retained sufficiently on the cell surface in several epithelial cancers, thereby making it suitable for pretargeted imaging and therapy of various Trop-2-expressing carcinomas.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research Radiopharmaceutical Chemistry and Applications Immunotherapy and Immune Responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Nuclear Medicine

Volume 53, Issue 10, pp. 1625-1632

DOI: 10.2967/jnumed.112.104364

Field-Weighted Citation Impact: 2.99