Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans

2011367 citationsJournal Articlehybrid Open Access

Authors

Michael A. Nauck · Diabeteszentrum Bad Lauterberg

Jens J. Holst · University of Copenhagen

Abstract

The GLP-1-induced delay in gastric emptying is subject to rapid tachyphylaxis at the level of vagal nervous activation. As a consequence, postprandial glucose control by GLP-1 is attenuated after its chronic administration.

Topics & Keywords

Diabetes Treatment and Management Pancreatic function and diabetes Gastroesophageal reflux and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 60, Issue 5, pp. 1561-1565

DOI: 10.2337/db10-0474

Field-Weighted Citation Impact: 17.97