Production of Fumonisin Analogs by <i>Fusarium</i> Species

The fumonisins, a family of food-borne carcinogenic mycotoxins, were first isolated in 1988 (21) from cultures of Fusarium verticillioides (Sacc.)Nirenberg (previously known as Fusarium moniliforme Sheldon).During the same year, the structures of the fumonisins were elucidated (6) and fumonisin B 1 was shown to cause equine leukoencephalomalacia (34).There have been numerous publications dealing with this group of novel, carcinogenic mycotoxins, and comprehensive reviews of different aspects of the fumonisins are available (20,22,23,24,35,36,37,41,43,46,52,55,60,61,66).Due to the widespread occurrence of the fumonisins in maize, a dietary staple in many countries, the carcinogenic risk of fumonisins to humans was evaluated by the International Agency for Research on Cancer in 1993, and the toxins produced by F. moniliforme were evaluated as "Group 2B carcinogens," i.e., probably carcinogenic to humans (24).This review focuses on the Fusarium species that produce fumonisins and the fumonisin analogs produced by each of these species.