Quantitative Analysis of the Bidirectional Fetomaternal Transfer of Nucleated Cells and Plasma DNA

2000242 citationsJournal Articlebronze Open Access

Authors

Tze Kin Lau · Chinese University of Hong Kong

Tse Ngong Leung · Chinese University of Hong Kong

Abstract

This study indicated that significantly more fetal DNA is present in the plasma of pregnant women compared with DNA from the cellular fraction of maternal blood. In addition, maternal DNA was demonstrated in both the cellular and plasma fractions of cord blood after delivery. This study has therefore determined the fundamental quantitative values for the bidirectional fetomaternal cellular and plasma DNA traffic.

Topics & Keywords

Prenatal Screening and Diagnostics Renal and related cancers Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 46, Issue 9, pp. 1301-1309

DOI: 10.1093/clinchem/46.9.1301

Field-Weighted Citation Impact: 26.10