Anti-inflammatory and Upper Gastrointestinal Effects of Celecoxib in Rheumatoid Arthritis

1999803 citationsJournal Article

Authors

Lee S. Simon · Beth Israel Deaconess Medical Center

Arthur L. Weaver · Beth Israel Deaconess Medical Center

David Y. Graham · Beth Israel Deaconess Medical Center

Alan Kivitz · Beth Israel Deaconess Medical Center

Peter E. Lipsky · Beth Israel Deaconess Medical Center

Richard C. Hubbard · Beth Israel Deaconess Medical Center

Peter C. Isakson

Abstract

In this study, all dosages of celecoxib were efficacious in the treatment of rheumatoid arthritis and did not affect COX-1 activity in the GI tract mucosa as evidenced by less frequent incidence of endoscopic ulcers compared with naproxen.

Topics & Keywords

Inflammatory mediators and NSAID effects Synthesis of β-Lactam Compounds Drug-Induced Adverse Reactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 282, Issue 20, pp. 1921-1921

DOI: 10.1001/jama.282.20.1921

Field-Weighted Citation Impact: 65.32