A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

2015105 citationsJournal Articlegold Open Access

Authors

Akihito Kawazoe · National Cancer Center Hospital East

Kohei Shitara · National Cancer Center Hospital East

Shota Fukuoka · National Cancer Center Hospital East

Yasutoshi Kuboki · National Cancer Center Hospital East

Hideaki Bando · National Cancer Center Hospital East

Wataru Okamoto · National Cancer Center Hospital East

Takashi Kojima

Abstract

Other RAS and BRAF mutations were observed in KRAS exon 2 wild-type tumors, which were associated with some clinicopathological features and resistance to anti-EGFR therapy in our patient cohort.

Topics & Keywords

Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer Gastric Cancer Management and Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cancer

Volume 15, Issue 1, pp. 258-258

DOI: 10.1186/s12885-015-1276-z

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