Microsatellite Instability and Colorectal Cancer Prognosis

2005382 citationsJournal Articlebronze Open Access

Authors

Piero Benatti

Roberta Gafà · University of Ferrara

Daniela Barana · University of Verona

Massimiliano Marino

A Scarselli

Monica Pedroni

Iva Maestri · University of Ferrara

Laura Guerzoni · University of Ferrara

Luca Roncucci

Abstract

The type of genomic instability could influence the prognosis of CRC, in particular in stages II and III. Fluorouracil-based chemotherapy does not seem to improve survival among MSI-H patients. The survival benefit for patients with hereditary non-polyposis colorectal cancer is mainly determined by younger age and less advanced stage as compared with sporadic MSI-H counterpart.

Topics & Keywords

Genetic factors in colorectal cancer Colorectal Cancer Screening and Detection Colorectal Cancer Treatments and Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 11, Issue 23, pp. 8332-8340

DOI: 10.1158/1078-0432.ccr-05-1030

Field-Weighted Citation Impact: 11.90