The Lethal Effect of a Benzamide Derivative, 3-Methoxybenzamide, Can Be Suppressed by Mutations within a Cell Division Gene, <i>ftsZ</i> , in <i>Bacillus subtilis</i>

199986 citationsJournal Articlebronze Open Access

Authors

Yoshiaki Ohashi · Saint Paul University

Yoshie Chijiiwa · St. Paul's University

Koichiro Suzuki · St. Paul's University

Kouki Takahashi · St. Paul's University

Hideaki Nanamiya · St. Paul's University

Tsutomu Sato · Tokyo University of Agriculture and Technology

Y Hosoya ·

Abstract

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

Topics & Keywords

Toxin Mechanisms and Immunotoxins Bacterial Genetics and Biotechnology PARP inhibition in cancer therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Bacteriology

Volume 181, Issue 4, pp. 1348-1351

DOI: 10.1128/jb.181.4.1348-1351.1999

Field-Weighted Citation Impact: 0.41