Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice

2008154 citationsJournal Article

Authors

Hantz C. Hercule · Chinese University of Hong Kong

Wolf‐Hagen Schunck

Volkmar Groß · Chinese University of Hong Kong

Jasmin Seringer · Chinese University of Hong Kong

Fung Ping Leung · Chinese University of Hong Kong

Steven M. Weldon · Chinese University of Hong Kong

Andrey C. da Costa Gonçalves · Chinese University of Hong Kong

Abstract

Our data indicate that the EDHF response in mice is caused by hydrogen peroxide, but not by P450 eicosanoids. Moreover, P450 eicosanoids are vasodilatory, largely through their ability to activate endothelial NO synthase (eNOS) and NO release.

Topics & Keywords

Eicosanoids and Hypertension Pharmacology Free Radicals and Antioxidants Biochemical effects in animals

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 29, Issue 1, pp. 54-60

DOI: 10.1161/atvbaha.108.171298

Field-Weighted Citation Impact: 10.70