Cytochrome P-450: Structure, Mechanism, and Biochemistry

Recent Work: Models and Mechanisms of Cytochrome P450 Action (J.T. Groves, Y. Han). Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450 (L.J. Marnett, T.A. Kennedy). Structurally Defined Bacterial Enzymes: Twentyfive Years of P450cam Research: Mechanistic Insights into Oxygenase Catalysis (E.J. Mueller et al.). Structural Studies on Prokaryotic Cytochromes P450 (T.L. Poulos et al.). Bacterial P450s: Structural Similarities and Functional Differences (J.A. Peterson, S.E. GrahamLorence). Structures and Mechanisms of Membranebound P450 Enzymes: Structures of Eukaryotic Cytochrome P450 Enzymes (C. von Wachenfeldt, E.F. Johnson). NADPH Cytochrome P450 Reductase and Its Structural and Functional Domains (H.W. Strobel et al.). Oxygen Activation and Reactivity (P.R. Ortiz de Montellano). Inhibition of Cytochrome P450 Enzymes (P.R. Ortiz de Montellano, M.A. Correia). Regulatory Mechanisms and Physiological Roles of Cytochrome P450: Induction of Cytochrome P450 Enzymes That Metabolize Xenobiotics (J.P. Whitlock, Jr., M.S. Denison). Hormonal Regulation of Liver Cytochrome P450 Enzymes (D.J. Waxman, K.H. Chang). Regulation of Steroidogenic and Related P450s (N. Kagawa, M.R. Waterman). Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids (J.H. Capdevila et al.). Human Cytochrome P450 Enzymes (F.P. Guengerich). Heme Thiolate Proteins Different from Cytochromes P450 Catalyzing Monooxygenations (D. Mansuy, J.P. Renaud). Appendixes. Index.