Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial

2006602 citationsJournal Articlegold Open Access

Authors

Daniel G. Lee · Massachusetts General Hospital

Jonathan M. Urbach · Massachusetts General Hospital

Gang Wu · Harvard University

Nicole T. Liberati · Massachusetts General Hospital

Rhonda Feinbaum · Massachusetts General Hospital

Sachiko Miyata · Harvard University

Lenard T. Diggins

Abstract

Genes required for pathogenicity in one strain of P. aeruginosa are neither required for nor predictive of virulence in other strains. We therefore propose that virulence in this organism is both multifactorial and combinatorial, the result of a pool of pathogenicity-related genes that interact in various combinations in different genetic backgrounds.

Topics & Keywords

Bacterial biofilms and quorum sensing Vibrio bacteria research studies Antibiotic Resistance in Bacteria

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Genome biology

Volume 7, Issue 10, pp. R90-R90

DOI: 10.1186/gb-2006-7-10-r90

Field-Weighted Citation Impact: 9.63