Growth-Inhibitory Effects of Artesunate, Pyrimethamine, and Pamaquine against<i>Babesia equi</i>and<i>Babesia caballi</i>in In Vitro Cultures

Three antimalarial drugs, artesunate, pyrimethamine, and pamaquine, were evaluated for their growth-inhibitory effects against Babesia equi and Babesia caballi in in vitro culture. B. equi was more resistant to pyrimethamine than B. caballi. B. equi was also found to be more sensitive to artesunate and pamaquine than B. caballi. Of the three compounds, pyrimethamine gave the most promise for in vivo effectiveness.