Response of Retinoblastoma With Vitreous Tumor Seeding to Adenovirus-Mediated Delivery of Thymidine Kinase Followed by Ganciclovir

2005144 citationsJournal Articlebronze Open Access

Authors

Patricia Chévez‐Barrios · Houston Methodist

Murali Chintagumpala · Methodist Hospital

William F. Mieler · Methodist Hospital

Evelyn A. Paysse · Baylor College of Medicine

Milton Boniuk · Houston Methodist

Claudia A. Kozinetz · Methodist Hospital

Mary Y. Hurwitz ·

Abstract

AdV-TK followed by ganciclovir can be administered safely to children with retinoblastoma. Suicide gene therapy may contribute to the treatment of children with retinoblastoma tumor seeds in the vitreous, a resistant complication of retinoblastoma.

Topics & Keywords

Ocular Oncology and Treatments Virus-based gene therapy research Corneal Surgery and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 23, Issue 31, pp. 7927-7935

DOI: 10.1200/jco.2004.00.1883

Field-Weighted Citation Impact: 7.49