Response to Comment on: Thallas-Bonke et al. (2008) Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway: <i>Diabetes</i> 57:460–469, 2008

We thank Dr. Yamagishi for his constructive comments (1) on our recent article (2). In response, we agree that it is possible for protein kinase C–α (PKC-α) to be a downstream signaling molecule of NADPH oxidase, further validating this PKC isoform as an important therapeutic target for the treatment of progressive diabetic nephropathy. In the schema of Fig. 7 in our recent …