M-Type Phospholipase A <sub>2</sub> Receptor as Target Antigen in Idiopathic Membranous Nephropathy

20092,282 citationsJournal Articlebronze Open Access

Authors

Laurence H. Beck · Boston University

Ramon Bonegio · Boston University

Gérard Lambeau · Institut de Pharmacologie Moléculaire et Cellulaire

David M. Beck · Boston University

David W. Powell · University of Louisville

Timothy D. Cummins · University of Louisville

Jon B. Klein ·

Abstract

A majority of patients with idiopathic membranous nephropathy have antibodies against a conformation-dependent epitope in PLA(2)R. PLA(2)R is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that PLA(2)R is a major antigen in this disease.

Topics & Keywords

Renal Diseases and Glomerulopathies Autoimmune Bullous Skin Diseases Coagulation, Bradykinin, Polyphosphates, and Angioedema

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 1, pp. 11-21

DOI: 10.1056/nejmoa0810457

Field-Weighted Citation Impact: 37.61