Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis

20042,348 citationsJournal Article

Authors

Steven E. Nissen · Cleveland Clinic Lerner College of Medicine

E. Murat Tuzcu · Cleveland Clinic

Paul Schoenhagen · Cleveland Clinic

B. Greg Brown · Cleveland Clinic

Peter Ganz · Cleveland Clinic

Robert A. Vogel · Cleveland Clinic

Tim Crowe ·

Abstract

For patients with coronary heart disease, intensive lipid-lowering treatment with atorvastatin reduced progression of coronary atherosclerosis compared with pravastatin. Compared with baseline values, patients treated with atorvastatin had no change in atheroma burden, whereas patients treated with pravastatin showed progression of coronary atherosclerosis. These differences may be related to the greater reduction in atherogenic lipoproteins and C- reactive protein in patients treated with atorvastatin.

Topics & Keywords

Lipoproteins and Cardiovascular Health Coronary Interventions and Diagnostics Cardiac Imaging and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 291, Issue 9, pp. 1071-1071

DOI: 10.1001/jama.291.9.1071

Field-Weighted Citation Impact: 253.25