Fungal Infections Associated with Contaminated Methylprednisolone Injections

2012231 citationsJournal Article

Authors

Rachel M. Smith · Epidemic Intelligence Service

Melissa K. Schaefer

Marion Kainer · Tennessee Department of Health

Matt P. Wise

Jennie Finks · Michigan Department of Health and Human Services

Joan Duwve · Indiana State Department of Health

Elizabeth Fontaine · Virginia Department of Health

Alvina Chu

Abstract

Analysis of data from a large, multistate outbreak of fungal infections showed substantial morbidity and mortality. The infections were associated with injection of a contaminated glucocorticoid medication from a single compounding pharmacy. Rapid public health actions included prompt recall of the implicated product, notification of exposed persons, and early outreach to clinicians.

Topics & Keywords

Antifungal resistance and susceptibility Intramuscular injections and effects Antibiotics Pharmacokinetics and Efficacy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 369, Issue 17, pp. 1598-1609

DOI: 10.1056/nejmoa1213978

Field-Weighted Citation Impact: 13.46