Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

2008142 citationsJournal Articlegreen Open Access

Authors

Nicole Gellings Lowe · San Diego State University

James S. Swaney · San Diego State University

Roger A. Sabbadini · San Diego State University

Abstract

These findings suggest that TGF-beta-stimulated collagen production in CF involves 'inside-out' S1P signalling whereby S1P produced intracellularly by SphK1 can be released and act in an autocrine/paracrine fashion to activate S1P2 and increase collagen production.

Topics & Keywords

Cellular Mechanics and Interactions Sphingolipid Metabolism and Signaling Cellular transport and secretion

Publication Details

Published in: Cardiovascular Research

Volume 82, Issue 2, pp. 303-312

DOI: 10.1093/cvr/cvp056

Field-Weighted Citation Impact: 2.52

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Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

Authors

Abstract

Topics & Keywords

Publication Details