Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

2010398 citationsJournal Article

Authors

Nicolas Riteau · Université d'Orléans

Paméla Gasse · Université d'Orléans

Louis Fauconnier · Université d'Orléans

Aurélie Gombault · Université d'Orléans

Marion Couegnat · Université d'Orléans

Lizette Fick · University of Cape Town

Jean Kanellopoulos ·

Abstract

ATP released from BLM-injured lung cells constitutes a major endogenous danger signal that engages the P2X(7) receptor/pannexin-1 axis, leading to IL-1β maturation and lung fibrosis.

Topics & Keywords

Adenosine and Purinergic Signaling Neonatal Respiratory Health Research Restraint-Related Deaths

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 182, Issue 6, pp. 774-783

DOI: 10.1164/rccm.201003-0359oc

Field-Weighted Citation Impact: 18.03