Molecular characteristics of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis isolates from the Russian Federation

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Authors

М. В. Афанасьев · Ministry of Health of the Russian Federation

Larisa N. Ikryannikova · Research Institute of Physical Chemical Medicine

Elena N. Ilina · Research Institute of Physical Chemical Medicine

Sidorenko Sv · Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Alexey V. Kuźmin · Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences

Е. Е. Ларионова · Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences

Abstract

Molecular analysis of the loci of rpoB and katG genes and the inhA promoter region of 412 M. tuberculosis clinical isolates from various parts of the Russian Federation was carried out. The new MALDI-TOF MS-based method may be used for rapid and accurate monitoring of the spread of drug resistance.

Topics & Keywords

Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Diagnosis and treatment of tuberculosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 59, Issue 6, pp. 1057-1064

DOI: 10.1093/jac/dkm086

Field-Weighted Citation Impact: 2.98