Microtube Device for Selectin-Mediated Capture of Viable Circulating Tumor Cells from Blood

2012102 citationsJournal Articlebronze Open Access

Authors

Alun D. Hughes · Cornell University

Jeff Mattison · Cornell University

Laura T. Western · Cornell University

John D. Powderly · Carolina BioOncology Institute

Bryan T. Greene · Carolina BioOncology Institute

Michael R. King · Cornell University

Abstract

The device successfully isolates viable CTCs from both blood and buffy coat samples. The approximately 50% capture rate with purities >50% with the nanotube coating demonstrates the functionality of this device in a clinical setting and opens the door for personalized cancer therapies.

Topics & Keywords

Cancer Cells and Metastasis Cell Adhesion Molecules Research Cellular Mechanics and Interactions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 58, Issue 5, pp. 846-853

DOI: 10.1373/clinchem.2011.176669

Field-Weighted Citation Impact: 8.01