A Global Comparative Evaluation of Commercial Immunochromatographic Rapid Diagnostic Tests for Visceral Leishmaniasis

2012171 citationsJournal Articlehybrid Open Access

Authors

Jane Cunningham · Special Programme for Research and Training in Tropical Diseases

Epco Hasker · Instituut voor Tropische Geneeskunde

Murari Lal Das · Rajendra Memorial Research Institute of Medical Sciences

Sayda El Safi · University of Khartoum

Hiro Goto · Instituto de Medicina Avançada

Dinesh Mondal · International Centre for Diarrhoeal Disease Research

Margaret Mbuchi

Abstract

Diagnostic accuracy of VL RDTs varies between the major endemic regions. Many tests performed well and showed good heat stability in the ISC; however, reduced sensitivity against Brazilian and East African panels suggests that in these regions, used alone, several RDTs are inadequate for excluding a VL diagnosis. More research is needed to assess ease of use and to compare performance using whole blood instead of serum and in patients coinfected with human immunodeficiency virus.

Topics & Keywords

Research on Leishmaniasis Studies Trypanosoma species research and implications

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Clinical Infectious Diseases

Volume 55, Issue 10, pp. 1312-1319

DOI: 10.1093/cid/cis716

Field-Weighted Citation Impact: 13.20