Preexposure Prophylaxis for HIV Infection among African Women

20121,602 citationsJournal Articlebronze Open Access

Authors

Lut Van Damme · Family Health International 360

Amy Corneli · Family Health International 360

Khatija Ahmed · Setshaba Research Centre

Kawango Agot · Impact Research and Development Organization

Johan Lombaard

Saidi Kapiga · Kilimanjaro Christian Medical Centre

Mookho Malahleha · Setshaba Research Centre

Abstract

Prophylaxis with TDF-FTC did not significantly reduce the rate of HIV infection and was associated with increased rates of side effects, as compared with placebo. Despite substantial counseling efforts, drug adherence appeared to be low. (Supported by the U.S. Agency for International Development and others; FEM-PrEP ClinicalTrials.gov number, NCT00625404.).

Topics & Keywords

HIV/AIDS Research and Interventions HIV/AIDS drug development and treatment HIV, Drug Use, Sexual Risk

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 367, Issue 5, pp. 411-422

DOI: 10.1056/nejmoa1202614

Field-Weighted Citation Impact: 89.06