Thymidylate Synthase Gene Polymorphism Predicts Toxicity in Colorectal Cancer Patients Receiving 5-Fluorouracil-based Chemotherapy

2004241 citationsJournal Article

Authors

Thierry Lecomte

Jean‐Marc Ferraz · Hôpital Européen

Franck Zinzindohoué · Assistance Publique – Hôpitaux de Paris

Marie‐Anne Loriot · Inserm

David‐Alexandre Trégouët · Sorbonne Université

Bruno Landi

Anne Berger · Hôpital Européen

Paul‐Henri Cugnenc ·

Abstract

This study demonstrated that TYMS genotyping could be of help in predicting toxicity to 5-FU-based chemotherapy. TYMS genotyping might make it possible to individualize treatment for patients with colorectal cancer.

Topics & Keywords

Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer Hepatocellular Carcinoma Treatment and Prognosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 10, Issue 17, pp. 5880-5888

DOI: 10.1158/1078-0432.ccr-04-0169

Field-Weighted Citation Impact: 6.59