Infusion of Human Umbilical Cord Blood Cells in a Rat Model of Stroke Dose-Dependently Rescues Behavioral Deficits and Reduces Infarct Volume

2004380 citationsJournal Articlebronze Open Access

Authors

Martina Vendrame · Saneron CCEL Therapeutics (United States)

J. V. CASSADY · Saneron CCEL Therapeutics (United States)

Jennifer D. Newcomb · Saneron CCEL Therapeutics (United States)

Tanya L. Butler · Saneron CCEL Therapeutics (United States)

Keith R. Pennypacker · Saneron CCEL Therapeutics (United States)

Tanja Zigova · Saneron CCEL Therapeutics (United States)

Cyndy D. Sanberg

Abstract

These results extend previous observations of HUCBC infusion in the MCAO rat stroke model by demonstrating a dose relationship between HUCBC, behavioral improvement, and neuronal sparing.

Topics & Keywords

Mesenchymal stem cell research Neurogenesis and neuroplasticity mechanisms Neuroinflammation and Neurodegeneration Mechanisms

Publication Details

Published in: Stroke

Volume 35, Issue 10, pp. 2390-2395

DOI: 10.1161/01.str.0000141681.06735.9b

Field-Weighted Citation Impact: 10.49

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Infusion of Human Umbilical Cord Blood Cells in a Rat Model of Stroke Dose-Dependently Rescues Behavioral Deficits and Reduces Infarct Volume

Authors

Abstract

Topics & Keywords

Publication Details