High Prevalence of Anal Human Papillomavirus–Associated Cancer Precursors in a Contemporary Cohort of Asymptomatic HIV-Infected Women

HIV-infected women with a history of HPV-associated cervical disease are at increased risk for HG-AIN+ and should be offered anal cancer screening. Anal cytology and HPV-16 genotyping had the best screening performance. Anal cytology is easy to perform routinely; it may be the best candidate for screening for HG-AIN among HIV-infected women.