The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats

2011365 citationsJournal Article

Authors

Evelyn Jantscher‐Krenn · Research Center Pharmaceutical Engineering (Austria)

Monica Zherebtsov · University of California, San Diego

Caroline Nissan · University of California, San Diego

Kerstin Goth · Children's Hospital of Los Angeles

Yigit S. Guner · Children's Hospital of Los Angeles

Natasha Naidu · University of California, San Diego

Biswa Choudhury

Abstract

HMO reduce NEC in neonatal rats and the effects are highly structure specific. If these results translate to NEC in humans, DSLNT could be used to prevent or treat NEC in formula-fed infants, and its concentration in the mother's milk could serve as a biomarker to identify breast-fed infants at risk of developing this disorder.

Topics & Keywords

Infant Nutrition and Health Neonatal Respiratory Health Research Pediatric Hepatobiliary Diseases and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 61, Issue 10, pp. 1417-1425

DOI: 10.1136/gutjnl-2011-301404

Field-Weighted Citation Impact: 11.09