Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

2012531 citationsReviewgold Open Access

Authors

Shama D. Ahuja

David Ashkin

Monika Avendano · University of Toronto

Rita Banerjee · Mayo Clinic

Melissa Bauer · McGill University

J Bayona · Dartmouth College

Mercedes C. Becerra · Partners In Health

Andrea Benedetti ·

Abstract

In this individual patient data meta-analysis of observational data, improved MDR-TB treatment success and survival were associated with use of certain fluoroquinolones, ethionamide, or prothionamide, and greater total number of effective drugs. However, randomized trials are urgently needed to optimize MDR-TB treatment. Please see later in the article for the Editors' Summary.

Topics & Keywords

Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Pneumonia and Respiratory Infections

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 9, Issue 8, pp. e1001300-e1001300

DOI: 10.1371/journal.pmed.1001300

Field-Weighted Citation Impact: 29.04