Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

2008321 citationsReviewbronze Open Access

Authors

Malcolm Macleod · National Stroke Foundation

H. Bart van der Worp · National Stroke Foundation

Emily S. Sena · National Stroke Foundation

David W. Howells · University of Edinburgh

Ulrich Dirnagl · University of Edinburgh

Geoffrey A. Donnan · National Stroke Foundation

Abstract

The reported efficacy of NXY-059 in animal models of stroke is confounded by low study quality. The failure of SAINT II highlights the need for substantial improvements in the design, conduct, and reporting of animal studies; journals can play an important role in this by adopting standards for animal studies similar to those agreed over 10 years ago for clinical trials.

Topics & Keywords

Animal testing and alternatives Computational Drug Discovery Methods

Publication Details

Published in: Stroke

Volume 39, Issue 10, pp. 2824-2829

DOI: 10.1161/strokeaha.108.515957

Field-Weighted Citation Impact: 22.30

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Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Authors

Abstract

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Publication Details