MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1

2009479 citationsJournal Article

Authors

Rossella Menghini · United States Nuclear Regulatory Commission

Viviana Casagrande · United States Nuclear Regulatory Commission

Marina Cardellini · United States Nuclear Regulatory Commission

Eugenio Martelli · United States Nuclear Regulatory Commission

Alessandro Terrinoni · United States Nuclear Regulatory Commission

Francesca Amati · United States Nuclear Regulatory Commission

Abstract

Our data pinpoint miR-217 as an endogenous inhibitor of SirT1, which promotes endothelial senescence and is potentially amenable to therapeutic manipulation for prevention of endothelial dysfunction in metabolic disorders.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 120, Issue 15, pp. 1524-1532

DOI: 10.1161/circulationaha.109.864629

Field-Weighted Citation Impact: 10.19