KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

2008198 citationsJournal Article

Authors

Joost O. Fledderus · University of Eastern Finland

Reinier A. Boon · University of Eastern Finland

Oscar L. Volger · University of Eastern Finland

Hanna Hurttila · University of Eastern Finland

Seppo Ylä‐Herttuala · University of Eastern Finland

Hans Pannekoek · University of Eastern Finland

Anna–Liisa Levonen

Abstract

We report that KLF2 substantially enhances antioxidant activity of Nrf2 by increasing its nuclear localization and activation. The synergistic activity of these two transcription factors forms a major contribution to the shear stress-elicited transcriptome in endothelial cells.

Topics & Keywords

Kruppel-like factors research Genomics, phytochemicals, and oxidative stress IL-33, ST2, and ILC Pathways

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 28, Issue 7, pp. 1339-1346

DOI: 10.1161/atvbaha.108.165811

Field-Weighted Citation Impact: 4.85

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KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

Authors

Abstract

Topics & Keywords

Publication Details