Inhibitory Effect of Alginic Acids on Hyaluronidase and on Histamine Release from Mast Cells

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Authors

Masahiro Asada · National Institute of Advanced Industrial Science and Technology

Makiko Sugie · National Institute of Advanced Industrial Science and Technology

Mami Inoue · National Institute of Advanced Industrial Science and Technology

Kazuya Nakagomi · National Institute of Advanced Industrial Science and Technology

Seiji Hongō · Tohoku Medical and Pharmaceutical University

Katsumi Murata · Toyo Institute of Food Technology

Abstract

The effects of various types of alginic acid consisting of L-guluronic acids (G) and D-mannuronic acids (M) on hyaluronidase and mast cell degranulation were examined. Alginic acid with an M/G ratio of 1.0 exhibited the strongest inhibition of both activities, the higher molecular weight alginic acids of 150 to 370 kDa being preferable in both cases. Esterification of the carboxyl residue enhanced the latter activity.

Topics & Keywords

Mast cells and histamine Chemical Synthesis and Analysis Carbohydrate Chemistry and Synthesis

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Bioscience Biotechnology and Biochemistry

Volume 61, Issue 6, pp. 1030-1032

DOI: 10.1271/bbb.61.1030

Field-Weighted Citation Impact: 0.47