Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

2013196 citationsJournal Articlehybrid Open Access

Authors

Andrew Quirke · Institute of Rheumatology

Elena B. Lugli · Kennedy Center

Natalia Wegner · University of Oxford

Bart C Hamilton · University of Nebraska Medical Center

P. Charles · Institute of Rheumatology

Muslima Chowdhury · Nuffield Orthopaedic Centre

A. Jimmy Ytterberg ·

Abstract

The peptidyl citrulline-specific immune response to PPAD supports the hypothesis that, as a bacterial protein, it might break tolerance in RA, and could be a target for therapy.

Topics & Keywords

Rheumatoid Arthritis Research and Therapies Monoclonal and Polyclonal Antibodies Research Autoimmune Bullous Skin Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of the Rheumatic Diseases

Volume 73, Issue 1, pp. 263-269

DOI: 10.1136/annrheumdis-2012-202726

Field-Weighted Citation Impact: 15.63