A Network of Coiled‐Coil Associations Derived from Synthetic GCN4 Leucine‐Zipper Arrays

Two is better than one: Coiled-coil sequence motifs are versatile protein–protein interaction modules. Single and double substitutions of the GCN4 coiled coil (1, 2, and 3) showed that the core positions a and d in the third heptad act as a switch for the transition from the native homodimeric to homotrimeric structures. This creates a synthetic three-membered association network with monomeric, homotrimeric, and heterodimeric coiled-coil states. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603246_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.