ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

20096,613 citationsJournal Articlehybrid Open Access

Authors

Gabriela Bindea · Assistance Publique – Hôpitaux de Paris

Bernhard Mlecnik · Graz University of Technology

Hubert Hackl · Université Paris Cité

Pornpimol Charoentong · Sorbonne Université

Marie Tosolini · Université Paris Cité

Amos Kirilovsky · Graz University of Technology

Wolf H. Fridman

Abstract

We have developed ClueGO, an easy to use Cytoscape plug-in that strongly improves biological interpretation of large lists of genes. ClueGO integrates Gene Ontology (GO) terms as well as KEGG/BioCarta pathways and creates a functionally organized GO/pathway term network. It can analyze one or compare two lists of genes and comprehensively visualizes functionally grouped terms. A one-click update option allows ClueGO to automatically download the most recent GO/KEGG release at any time. ClueGO provides an intuitive representation of the analysis results and can be optionally used in conjunction with the GOlorize plug-in.

Topics & Keywords

Bioinformatics and Genomic Networks Biomedical Text Mining and Ontologies Gene expression and cancer classification

Publication Details

Published in: Bioinformatics

Volume 25, Issue 8, pp. 1091-1093

DOI: 10.1093/bioinformatics/btp101

Field-Weighted Citation Impact: 15.64

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ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

Authors

Abstract

Topics & Keywords

Publication Details