De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae

2012365 citationsJournal Articlegold Open Access

Authors

Frank Koopman · Delft University of Technology

Jules Beekwilder · Centre for BioSystems Genomics

Barbara Crimi · Delft University of Technology

Adèle van Houwelingen

Robert D. Hall · Centre for BioSystems Genomics

Dirk Bosch · Centre for BioSystems Genomics

Antonius JA van Maris · Delft University of Technology

Abstract

The results reported in this study demonstrate that S. cerevisiae is capable of de novo production of naringenin by coexpressing the naringenin production genes from A. thaliana and optimization of the flux towards the naringenin pathway. The engineered yeast naringenin production host provides a metabolic chassis for production of a wide range of flavonoids and exploration of their biological functions.

Topics & Keywords

Plant Gene Expression Analysis Plant biochemistry and biosynthesis Microbial Metabolic Engineering and Bioproduction

Publication Details

Published in: Microbial Cell Factories

Volume 11, Issue 1, pp. 155-155

DOI: 10.1186/1475-2859-11-155

Field-Weighted Citation Impact: 8.45

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De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae

Authors

Abstract

Topics & Keywords

Publication Details