ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver

2004217 citationsJournal Articlebronze Open Access

Authors

Paolo Parini · Wake Forest University

Matthew A. Davis · Wake Forest University

Aaron T. Lada · Wake Forest University

Sandra K. Erickson · Karolinska Institutet

Teresa L. Wright · Danderyds sjukhus

Ulf Gustafsson · San Francisco VA Medical Center

Staffan Sahlin ·

Abstract

The data suggest that in diseases in which dysregulation of cholesterol metabolism occurs, such as hypercholesterolemia and atherosclerosis, ACAT2 should be considered a target for prevention and treatment.

Topics & Keywords

Cholesterol and Lipid Metabolism Peroxisome Proliferator-Activated Receptors Lipid metabolism and biosynthesis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 110, Issue 14, pp. 2017-2023

DOI: 10.1161/01.cir.0000143163.76212.0b

Field-Weighted Citation Impact: 9.92